Discovery of a DNA Topoisomerase I Inhibitor Huanglongmycin N and Its Congeners from <i>Streptomyces</i> sp. CB09001
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https://figshare.com/articles/dataset/Discovery_of_a_DNA_Topoisomerase_I_Inhibitor_Huanglongmycin_N_and_Its_Congeners_from_i_Streptomyces_i_sp_CB09001/16899675
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资源简介：
Huanglongmycin (HLM) congeners G–N
(7–14) were isolated from Streptomyces sp. CB09001.
Among them, 10–12 possesses a tricyclic
scaffold with benzene-fused pyran/pyrone, confirmed by X-ray single
crystal diffraction analysis of 12. The structure–activity
relationship study of 1, 13, and 14 revealed not only the stronger cytotoxicity of 14 against
tested cancer cells but also the critical role of the C-7 ethyl group
of 14 in its binding to the DNA–topoisomerase
I complex.
创建时间：
2021-10-28
