The FLS (Fatty liver Shionogi) mouse, liver with non-alcoholic steatohepatitis (NASH)

Comparison between livers of FLS mice and livers of DS (DD shionogi) mice We used FLS mice as model animals of human NASH, while DS mice as control animals. FLS mice develops NASH spontaneously. DS mouse strain is a sister strain of the FLS mouse strain. We compared RNA from pooled livers of three FLS mice and three DS mice at 19 weeks. NASH in livers from FLS mice was confirmied pathologically while simple steatosis of DS mouse livers confirmed.FLS小鼠肝脏与DS（DD Shionogi）小鼠肝脏的对比研究。本研究以FLS小鼠作为人类非酒精性脂肪性肝炎（Nonalcoholic Steatohepatitis, NASH）的模式动物，以DS小鼠作为对照动物。FLS小鼠可自发罹患NASH。DS小鼠品系为FLS小鼠品系的姊妹近缘品系。我们对19周龄的3只FLS小鼠与3只DS小鼠的混合肝脏组织提取RNA并开展对比分析。经病理学检测证实，FLS小鼠肝脏存在NASH病变，而DS小鼠肝脏仅表现为单纯性脂肪变性。