5-Day Gavage Study of 4-Methylcyclohexanemethanol (CASRN: 34885-03-5) in Male Harlan Sprague Dawley Rats

The goal of this study was to characterize the potential toxicity and genomic benchmark dose of 4-methylcyclohexylmethanol in liver and kidney of male Harlan Sprague Dawley rats using a 5 day dose-response toxicogenomics study design. The 5 day study is used to quickly identify the dose levels where changes in molecular pathways occur. These dose level where pathway level effects begin to occur have been shown to provide a close approximation of a no effect dose level from more resource intensive guideline toxicological assessments.本研究旨在通过为期5天的剂量反应毒基因组学（dose-response toxicogenomics）研究设计，表征4-甲基环己基甲醇（4-methylcyclohexylmethanol）对雄性Harlan Sprague Dawley大鼠肝脏与肾脏的潜在毒性及基因组基准剂量。该5天周期的研究可快速识别出分子通路发生改变的剂量水平。已有研究证实，这类通路水平效应初始出现的剂量水平，可较为精准地近似替代资源消耗更高的标准毒理学评估所得的无效应剂量水平。