Depletion of Nrf2 leads to an increase in cellular ROS, reduced glutathione and thiols, and profound reprogramming of metabolism. Unbiased transcriptome analyses show that key enzymes of glycolysis, p

NIAID Data Ecosystem60

Crystal structure of PRMT5:MEP50 in complex with MTA and TNG462

蛋白质晶体

癌症靶向治疗

Crystal structure of PRMT5:MEP50 in complex with MTA and TNG462 Descriptor: 1,2-ETHANEDIOL, 5'-DEOXY-5'-METHYLTHIOADENOSINE, CHLORIDE ION, ... Authors: Whittington, D.A. Deposit date: 2025-01-31 Relea

Protein Data Bank Japan2025-03-19 更新30

Crystal structure of BRAF/MEK1 complex with NST-628 and an active RAF dimer

癌症靶向治疗

RAS信号通路抑制

Crystal structure of BRAF/MEK1 complex with NST-628 and an active RAF dimer Descriptor: 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Dual specificity mitogen-activated protein kinase kina

Protein Data Bank Japan2024-07-10 更新60

Predicting synthetic lethal interactions using conserved patterns in protein interaction networks

合成致死预测

癌症靶向治疗

In response to a need for improved treatments, a number of promising novel targeted cancer therapies are being developed that exploit human synthetic lethal interactions. This is facilitating personal

Figshare2019-04-17 更新40

Second-line lapatinib vs. trastuzumab univariate analysis.

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