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Outcomes of intrahepatic cholangiocarcinoma specific CRISPR screening in vivo. Outcomes of intrahepatic cholangiocarcinoma specific CRISPR screening in vivo

NIAID Data Ecosystem2026-03-13 收录

肝内胆管癌靶点发现

体内基因编辑

数据链接：

https://www.ncbi.nlm.nih.gov/bioproject/PRJNA788444 数据链接链接失效反馈

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资源简介：

This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series

应用场景：

创建时间：

2021-12-13

体内基因编辑

肥厚型心肌病

We assessed genome editing strategies to treat cardiomyopathy in mice including one or two doses of ABE8e, or one low, medium, or high dose of SaCas9 nuclease We conducted RNA analysis and genomic DNA

NIAID Data Ecosystem40

In vivo genome editing via CRISPR-Cas9 mediated homology-independent targeted integration. Mus musculus

体内基因编辑

CRISPR脱靶分析

Targeted deep sequencing amplicons of on- and predicted off-target sites in CRISPR-Cas9 mediated GFP knock-in liver of Ai14 mouse.

NIAID Data Ecosystem20

Outcomes of intrahepatic cholangiocarcinoma specific CRISPR screening in vivo [mouse exome]. Outcomes of intrahepatic cholangiocarcinoma specific CRISPR screening in vivo [mouse exome]

功能基因组学

体内基因编辑

We report the genertion of a gRNA library that induces mutations often found in intrahepatic cholangiocarcinoma. We use this to screen in vivo mutations that when lost act synergistically with mutant

NIAID Data Ecosystem20

Homo sapiens Raw sequence reads. Homo sapiens

体内基因编辑

prime编辑技术

Prime editors (PEs) mediate genome modification without utilizing double-stranded DNA breaks or exogenous donor DNA as a template. PEs facilitate nucleotide substitutions or local insertions or deleti

NIAID Data Ecosystem30

A multiplexed in vivo gene knockout approach to identify cancer drivers in small cell lung cancer [SCLC Tuba-seq]

功能基因组学

体内基因编辑

We generated a model of lentivirus-initiated mouse small cell lung cancer (SCLC) combined with CRISPR/Cas9 knockout and barcoding. We analyzed tumor suppressive functions of 39 gene candidates using t

NIAID Data Ecosystem20

Outcomes of intrahepatic cholangiocarcinoma specific CRISPR screening in vivo. Outcomes of intrahepatic cholangiocarcinoma specific CRISPR screening in vivo

资源简介：

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