Gene induction by the USP6 oncogene in response to interferon

We examined the role of the USP6 oncogene in the patient-derived immortalized ewing sarcoma cell line RD-ES. RNA-sequncing revealed that USP6 induces numerous genes that overlap with genes induced by interferon treatment. When USP6-expressing cells were treated with IFN, many of the overlapping genes were synergistically upregulated, indicating an overlap in signaling pathways. Overall design: Examine the effects of USP6 and/or IFN on gene induction in RD-ES cells