Reactions of Zirconocene Butadiyne or Monoyne Complexes with Nitriles: Straightfoward Synthesis of Functionalized Pyrimidines
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Zirconium-mediated multicomponent reactions of silyl-butadiynes with two molecules of aryl nitriles are described, which provide rapid access to polysubstituted pyrimidines in a regioselective manner and in one pot. Employing aliphatic nitriles results in coupling of only one nitrile, leading to the formation of enynyl ketones after hydrolysis. A zirconocene monoyne complex undergoes similar reactions with nitriles to form highly substituted pyrimidines.
创建时间：
2016-02-18
