Transcriptomic analysis in human 3D skin model injected with resorbable hyaluronic acid fillers reveals foreign body response [RIVM]

To unravel the molecular events caused by exposure to dermal fillers in a multi-cell type human 3D skin model and to link these events to the characteristics of the dermal fill-ers. The human Phenion® Full-Thickness Skin Model was injection with five experimental hyaluronic acid (HA) preparations with increasing cross-linking degree (RIVM1-5), and with the non-resorbable filler Bio-Alcamid®