The goal is to assess whether interferon-inducible RNA regulates type I IFN through cytosolic RNA sensor MDA5. Huh7 cells were treated with or without IFN beta. Anti-MDA5 immunoprecipitation was condu

NIAID Data Ecosystem50

Single cell transcriptomic analysis (InDrops) of mouse FoxP3- CD4+ Tconv cells and FoxP3+ regulatory CD4+ T cells isolated from secondary lymphoid organs. Single cell transcriptomic analysis (InDrops) of mouse FoxP3- CD4+ Tconv cells and FoxP3+ regulatory CD4+ T cells isolated from secondary lymphoid organs

单细胞转录组学

T细胞免疫学

Single cell transcriptomic analysis (InDrops) of mouse FoxP3- CD4+ Tconv cells and FoxP3+ regulatory CD4+ T cells isolated from secondary lymphoid organs Overall design: Single cells were sorted by fl

NIAID Data Ecosystem40

Expression data from innate and conventional CD8+ T cell populations from naïve CXCR3-GFP Reporter mice

T细胞免疫学

基因表达谱分析

Innate CD8+ T cells are a heterogeneous population with developmental pathways distinct from conventional CD8+ T cells. Their biology, classification and functions remain incompletely understood. We r

NIAID Data Ecosystem50

A Robust Induction of Type III Interferons and Chemokines Defines a Unique Pattern of Hepatic Innate Immunity in Response to Hepatitis C Virus Infection

丙型肝炎免疫机制

干扰素信号通路

Recent identification of IL28B gene polymorphisms associated with hepatitis C virus (HCV) clearance suggests a role for type III interferons (IFNs) in hepatitis C infection. The function of type III I

NIAID Data Ecosystem40

Self-reactivity shapes functional diversity of naive CD8+ T cells by co-opting tonic type I interferon

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