Synthesis of Chiral Azabicycles from Pyroglutaminols
收藏NIAID Data Ecosystem2026-03-09 收录
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The stereocontrolled synthesis of a range of substituted bicyclic morpholine and piperazine derivatives is reported from substituted pyroglutaminols via an intramolecular SN2 cyclization as the key step. This enantiospecific approach toward chiral bicyclic morpholines and piperazines offers new opportunities to access these challenging ring systems, which are becoming increasingly common motifs in drug discovery.
创建时间：
2016-10-31
