Diastereoselective Base-Catalyzed Formal [4 + 2] Cycloadditions of <i>N</i>‑Sulfonyl Imines and Cyclic Anhydrides
收藏NIAID Data Ecosystem2026-03-10 收录
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A diastereoselective base-catalyzed Mannich reaction of cyclic, enolizable anhydrides and N-sulfonyl imines for the synthesis of δ-lactams is reported. This anhydride Mannich reaction tolerates imines derived from aryl and enolizable aldehydes. A base-catalyzed product epimerization pathway ensures high anti diastereoselectivity in aryl and achiral enolizable imines.
创建时间：
2017-05-04
