GECKO sequencing

NIAID Data Ecosystem2026-03-14 收录

药物基因富集分析

癌症靶向治疗

数据链接：

https://www.ncbi.nlm.nih.gov/bioproject/PRJNA903183 数据链接链接失效反馈

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资源简介：

Goal of this study is to analyze gene enrichment comparing samples of treated (Brigatinib or Ceritinib, 300nM and 750nM respectively) versus untreated (DMSO)

创建时间：

2022-11-18

Chromatin and transcriptome remodeling under EGFR chemical inhibition in lung cancer. Chromatin and transcriptome remodeling under EGFR chemical inhibition in lung cancer

癌症靶向治疗

表观遗传调控

This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series

NIAID Data Ecosystem200

Depletion of Nrf2 in pancreatic cancer cells shifts arginine metabolism into the phosphocreatine energy system. Depletion of Nrf2 in pancreatic cancer cells shifts arginine metabolism into the phosphocreatine energy system

癌细胞重编程

癌症靶向治疗

Depletion of Nrf2 leads to an increase in cellular ROS, reduced glutathione and thiols, and profound reprogramming of metabolism. Unbiased transcriptome analyses show that key enzymes of glycolysis, p

NIAID Data Ecosystem60

Crystal structure of PRMT5:MEP50 in complex with MTA and TNG462

蛋白质晶体

癌症靶向治疗

Crystal structure of PRMT5:MEP50 in complex with MTA and TNG462 Descriptor: 1,2-ETHANEDIOL, 5'-DEOXY-5'-METHYLTHIOADENOSINE, CHLORIDE ION, ... Authors: Whittington, D.A. Deposit date: 2025-01-31 Relea

Protein Data Bank Japan2025-03-19 更新30

Crystal structure of BRAF/MEK1 complex with NST-628 and an active RAF dimer

癌症靶向治疗

RAS信号通路抑制

Crystal structure of BRAF/MEK1 complex with NST-628 and an active RAF dimer Descriptor: 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Dual specificity mitogen-activated protein kinase kina

Protein Data Bank Japan2024-07-10 更新60

Predicting synthetic lethal interactions using conserved patterns in protein interaction networks

合成致死预测

癌症靶向治疗

In response to a need for improved treatments, a number of promising novel targeted cancer therapies are being developed that exploit human synthetic lethal interactions. This is facilitating personal

Figshare2019-04-17 更新40

GECKO sequencing

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