基于金属儿茶酚胺网络（MCN）通过铁增强羟基磷灰石纳米棒生物活性表面用于的骨组织工程

羟基磷灰石（HAP）是一种基于磷酸钙的无机性，构成骨骼和牙齿。 模仿天然骨磷灰石的纳米结构杆的合成吸引了显着的意义。 不幸的是，由于原始HAP的脆性，有限的强度，不受控制的浸出和表面性能不佳，因此原始HAP不适合临床翻译。 这些局限性需要减小尺寸，表面修饰和离子掺入以扩大其在骨骼重构中的范围。 在此，将铁增强的羟基磷灰石纳米棒（Fe-HAP）用作无机成分，并且用作表面功能修饰剂。 我们的研究强调，由于其Met-Al-Catechol网络（MCN）表面工程技术，与其他与其他有离子的纳米材料相比，Fe掺杂的HAP纳米材料对于开发生物活性表面更有希望。 已经对Fe-Hap和Fe-Hap/MCN纳米棒的纳米结构，表面化学，细胞核临床性和基质矿化特性进行了相对研究。 结果支持MCN涂层的纳米棒表面提高了有机/无机纳米材料之间的HAP细胞相容性，生物活性和相位兼容性，这对于骨骼重建至关重要.

Hydroxyapatite (HAP) is a calcium phosphate-based inorganic material that constitutes the primary mineral component of bones and teeth. The synthesis of nanostructured rods mimicking natural bone apatite has attracted significant research interest. Unfortunately, pristine HAP is unsuitable for clinical translation due to its inherent brittleness, limited mechanical strength, uncontrolled ion leaching, and poor surface properties. These limitations necessitate strategies including size reduction, surface modification, and ion doping to expand its application scope in bone reconstruction. Herein, iron-doped hydroxyapatite nanorods (Fe-HAP) are utilized as the inorganic constituent and serve as surface-functional modifiers. Our study highlights that Fe-doped HAP nanomaterials are more promising for developing bioactive surfaces compared to other ion-doped nanomaterials, owing to the Metal-Aluminum-Catechol Network (MCN) surface engineering strategy. A comparative investigation has been conducted on the nanostructure, surface chemistry, cytocompatibility, and matrix mineralization properties of Fe-HAP and Fe-HAP/MCN nanorods. The results demonstrate that MCN-coated nanorod surfaces enhance the cytocompatibility, bioactivity, and interfacial compatibility of HAP-based nanomaterials between organic and inorganic phases, which is critical for bone reconstruction.