On-target and Off-Target of mutant mice among different generations.

Figshare2025-12-03 更新00

On-target and Off-target Activities of RAG Are Restricted by Topological Chromatin Domains

RAG initiates V(D)J recombination in developing lymphocytes by generating "on-target" DNA double-stranded breaks at bona fide recombination signal sequence (RSS) pairs. We now employ RAG-generated DN

NIAID Data Ecosystem30

SMRT sequencing results showing on-target and off-target activity of HBV-ZFNs.

LQ, low quality; TS, target site; *Significance between Z1 and Z3 (p<0.01), Z1 and Z2 (p<0.001), Z2 and Z3 (p<0.001).

NIAID Data Ecosystem10