The genotype ratio was distorted after IVF with oocytes from <i>Shb</i> +/− mothers and <i>Shb</i> +/+ sperm.

Oocytes from +/− mothers were isolated, in vitro fertilized with +/+ sperm and differentiated in vitro as in Fig. 6. At 24 h after IVF the early embryos/oocytes were classified and genotyped. The absolute and relative (in percent) +/+ vs +/− embryos/oocytes are given for each category. * indicates p<0.05 when compared with the corresponding number of morulas using the Chi-square test. The total percentage +/+ genotype was 26% for 122 observations.