We found that ERbeta activated by ligand eithe E2 or LY3201 repressed AR activity and affected downstream genes regulated by AR Overall design: To investigate the mechanisms of action of ERÃ and its

NIAID Data Ecosystem70

Calculated Max and EC50 Responses of AIS GSF Cell Lines.

激素受体信号通路

剂量反应分析

Values calculated by applying the 4-parameter curve fit algorithm available in SigmaPlot to multiple replicate experiments. All data are presented as absolute numerical measurements. Calculated maxima

NIAID Data Ecosystem40

Transcript and protein profiling identify signaling, growth arrest, apoptosis and NFκB-survival signatures following GnRH receptor activation.

癌症分子机制

激素受体信号通路

Gonadotrophin-releasing hormone (GnRH) significantly inhibits proliferation of a proportion of cancer cell lines by activating GnRH receptor-G protein signaling. Therefore, manipulation of GnRH recept

NIAID Data Ecosystem80

Supplementary Material for: Androgen Receptor Mutations Are Associated with Altered Epigenomic Programming as Evidenced by HOXA5 Methylation

表观遗传学

激素受体信号通路

Male external genital differentiation is accompanied by implementation of a long-term, male-specific gene expression pattern indicating androgen programming in cultured genital fibroblasts. We hypothe

NIAID Data Ecosystem50