Small molecule-mediated ERO1A inhibition in restraining aggressive breast cancer

ChEBI2025-02-12 更新2026-07-12 收录

癌症靶向治疗

小分子药物

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https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-MTAB-14269 数据链接链接失效反馈

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Small molecule-mediated ERO1A inhibition in restraining aggressive breast cancer

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2025-02-12

Crystal structure of BRAF/MEK1 complex with NST-628 and an active RAF dimer

癌症靶向治疗

RAS信号通路抑制

Crystal structure of BRAF/MEK1 complex with NST-628 and an active RAF dimer Descriptor: 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Dual specificity mitogen-activated protein kinase kina

Protein Data Bank Japan2024-07-10 更新60

Crystal structure of PRMT5:MEP50 in complex with MTA and TNG462

蛋白质晶体

癌症靶向治疗

Crystal structure of PRMT5:MEP50 in complex with MTA and TNG462 Descriptor: 1,2-ETHANEDIOL, 5'-DEOXY-5'-METHYLTHIOADENOSINE, CHLORIDE ION, ... Authors: Whittington, D.A. Deposit date: 2025-01-31 Relea

Protein Data Bank Japan2025-03-19 更新30

Development of Aptamer-DNAzyme Based Metal-Nucleic Acid Frameworks for Gastric Cancer therapy

核酸适配体药物递送

癌症靶向治疗

All data from source data

NIAID Data Ecosystem20

Depletion of Nrf2 in pancreatic cancer cells shifts arginine metabolism into the phosphocreatine energy system. Depletion of Nrf2 in pancreatic cancer cells shifts arginine metabolism into the phosphocreatine energy system

癌细胞重编程

癌症靶向治疗

Depletion of Nrf2 leads to an increase in cellular ROS, reduced glutathione and thiols, and profound reprogramming of metabolism. Unbiased transcriptome analyses show that key enzymes of glycolysis, p

NIAID Data Ecosystem60

Table S2 from Disruption of TFIIH activities generates a stress gene expression response and reveals possible new targets against cancer

癌症靶向治疗

转录抑制响应

Disruption of the enzymatic activities of the transcription factor TFIIH by the small molecules Triptolide (TPL) or THZ1 could be used against cancer. Here, we used the MCF10A-ErSrc oncogenesis model

Figshare2020-06-01 更新30

Small molecule-mediated ERO1A inhibition in restraining aggressive breast cancer

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