EndoV-seq utilizes Endonuclease V (EndoV) to nick the inosine (I)-containing DNA strand of genomic DNA that has been deaminated by ABE in vitro. The treated DNA is then whole-genome sequenced to ident
Table 1 - Non-specific sgRNAs GeCKO v2 (human). This table represents the total of 5,664 sgRNAs within the entire GeCKO v2 library (half-libraries A and B combined) that recognise at least two identic
Even the latest generation of base editor (BE3) causes unwanted indels and non-C-to-T substitutions, compromising the fidelity of base editing outcome. Here we report a enhanced base editing system. T
