Highly Substituted 2,3-Dihydroisoxazoles by Et<sub>3</sub>N-Catalyzed Tandem Reaction of Electron-Deficient 1,3-Conjugated Enynes with Hydroxylamines
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An Et3N-catalyzed tandem reaction of electron-deficient 1,3-conjugated enynes with hydroxylamines was developed which provided rapid, metal-free, and regioselective access to highly substituted multifunctionalized 2,3-dihydroisoxazoles under mild conditions. The reactions of 3-(2-arylethynyl)-4H-chromen-4-ones with hydroxylamines afford β-amino enones under the same reaction conditions.
创建时间:
2010-04-16



