Next Generation Sequencing Analysis of SRSF1 flox/flox and SRSF1-KO pancreatic islet Transcriptome

we report insulin secretion defects in SRSF1 Ins2-Cre mice, in which SRSF1 is ablated in pancreatic beta cells. The control and SRSF1 Ins2-Cre gene in pancreatic beta cells mRNA profiles were generated by deep sequencing, using illumina novaseq 6000我们报道了SRSF1 Ins2-Cre小鼠的胰岛素分泌缺陷表型，该模型小鼠的胰腺胰岛β细胞中SRSF1基因被特异性敲除。本研究依托Illumina NovaSeq 6000测序平台开展深度测序，获取了对照组与该基因敲除小鼠胰腺胰岛β细胞的mRNA表达谱。