Retention behavior of analytes applying three micellar mobile phases

This dataset contains data representing the retention behavior obtained upon utilizing three micellar based mobile phases for the simultaneous determination of certain partial dopamine agonists that are used to overcome the withdrawal symptoms of abused drugs, namely aripiprazole, pramipexole, and piribedil. The studied drugs were separated using micellar liquid chromatography (MLC), hybrid micellar liquid chromatography (HMLC), and micro emulsion liquid chromatography (MELC). The resultant retention behavior of the studied drugs applying the three developed mobile phases were mathematically manipulated to select the suitable mobile phase for log p measurement of the concerned pharmaceuticals. Experimental determination of log Pm/w values using the three mobile phases demonstrates that HMLC is the mobile phase of choice since the obtained practical log Pm/w values were in accordance with the reported log P values, and calculated log P and log D values.本数据集收录了采用三种胶束基流动相时获得的保留行为数据，用于同时测定数种用于缓解滥用药物戒断症状的多巴胺部分激动剂，具体包括阿立哌唑（aripiprazole）、普拉克索（pramipexole）与吡贝地尔（piribedil）。所研究的受试药物分别通过胶束液相色谱（micellar liquid chromatography, MLC）、杂合胶束液相色谱（hybrid micellar liquid chromatography, HMLC）以及微乳液液相色谱（micro emulsion liquid chromatography, MELC）完成分离。针对采用三种所开发流动相时各受试药物的保留行为进行数学处理，以筛选出适用于目标药物log P测定的适宜流动相。采用三种流动相对log Pm/w值开展实验测定的结果显示，杂合胶束液相色谱（HMLC）为优选流动相，因其测得的实测log Pm/w值与已报道的log P值、计算得到的log P及log D值均保持一致。