Asymmetric [3 + 2] Cycloaddition of Methyleneindolinones with <i>N</i>,<i>N</i>′‑Cyclic Azomethine Imines Catalyzed by a <i>N</i>,<i>N</i>′‑Dioxide–Mg(OTf)<sub>2</sub> Complex
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A highly efficient chiral N,N′-dioxide–Mg(OTf)2 catalyst system has been developed for the asymmetric 1,3-dipolar cycloaddition between methyleneindolinones and N,N′-cyclic azomethine imines. The desired pyrazolidine products with contiguous quaternary–tertiary stereocenters were obtained in up to 99% yields with up to 99% ee and >19:1 dr under mild reaction conditions.
创建时间：
2016-02-13
