N5 Adduct of LSD1-CoREST in complex with MC4455

N5 Adduct of LSD1-CoREST in complex with MC4455 Descriptor: Lysine-specific histone demethylase 1A, REST corepressor 1, [[(2~{S},3~{R},4~{S},5~{S})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{S},3~{S},4~{R})-5-[5-[3-[4-[[4-[[(2~{S})-3-(3,4-dihydro-1~{H}-isoquinolin-2-yl)-2-oxidanyl-propyl]carbamoyl]pyridin-2-yl]amino]phenyl]propanoyl]-7,8-dimethyl-2,4-bis(oxidanylidene)-4~{a}~{H}-benzo[g]pteridin-10-yl]-2,3,4-tris(oxidanyl)pentyl] hydrogen phosphate Authors: Barone, M, Mattevi, A. Deposit date: 2024-04-15 Release date: 2025-04-23 Last modified: 2026-05-06 Method: X-RAY DIFFRACTION (3.36 Å) Cite: A synergistic interaction between PRMT5 and LSD1 inhibitors in AML. Sci Adv, 12, 2026