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Chromatin and transcriptome remodeling under EGFR chemical inhibition in lung cancer. Chromatin and transcriptome remodeling under EGFR chemical inhibition in lung cancer
This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series
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Crystal structure of BRAF/MEK1 complex with NST-628 and an active RAF dimer
Crystal structure of BRAF/MEK1 complex with NST-628 and an active RAF dimer Descriptor: 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Dual specificity mitogen-activated protein kinase kina
Protein Data Bank Japan2024-07-10 更新60
Crystal structure of PRMT5:MEP50 in complex with MTA and TNG462
Crystal structure of PRMT5:MEP50 in complex with MTA and TNG462 Descriptor: 1,2-ETHANEDIOL, 5'-DEOXY-5'-METHYLTHIOADENOSINE, CHLORIDE ION, ... Authors: Whittington, D.A. Deposit date: 2025-01-31 Relea
Protein Data Bank Japan2025-03-19 更新30
PARP15 catalytic domain in complex with OUL218
PARP15 catalytic domain in complex with OUL218 Descriptor: 4-(1,3-thiazol-5-ylmethoxy)benzamide, DIMETHYL SULFOXIDE, Protein mono-ADP-ribosyltransferase PARP15 Authors: Maksimainen, M.M, Murthy, S, Le
Protein Data Bank Japan2024-01-31 更新80
Depletion of Nrf2 in pancreatic cancer cells shifts arginine metabolism into the phosphocreatine energy system. Depletion of Nrf2 in pancreatic cancer cells shifts arginine metabolism into the phosphocreatine energy system
Depletion of Nrf2 leads to an increase in cellular ROS, reduced glutathione and thiols, and profound reprogramming of metabolism. Unbiased transcriptome analyses show that key enzymes of glycolysis, p
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