官方服务：
资源简介：
To screen any driver mutations from human tissue by base editor
应用场景：
创建时间：
2021-09-02
相关数据集
Homo sapiens Genome sequencing. Homo sapiens
To increase the targeting scope and diversify the editing patterns of base editors, we designed a subset of base editors derived from the Cas9 ortholog from Staphylococcus aureus (SaCas9) in which cyt
NIAID Data Ecosystem40
AAV Delivery of intein-split base editors
These data were generated by a series of experiments designed to optimized and validate base editing in vivo. We used protein inteins to split and deliver base editors, which are too large to be deliv
NIAID Data Ecosystem30
Homo sapiens Genome sequencing
To increase the targeting scope and diversify the editing patterns of base editors, we designed a subset of base editors derived from the Cas9 ortholog from Staphylococcus aureus (SaCas9) in which cyt
NIAID Data Ecosystem20
A base editor facilitates simultaneous purine and pyrimidine substitutions
We have developed the ACGBEmax system, which is created by fusing a dual-functional deaminase, an engineered N-methylpurine DNA glycosylase, and an evolved SRAP domain with nCas9 (D10A). This system e
NIAID Data Ecosystem30
Base editing effectively prevents the early-onset hypertrophic cardiomyopathy in Mybpc3 mutant mice
Pathogenic variants in MYBPC3 (myosin-binding protein C3) are the leading cause of genetic hypertrophic cardiomyopathy (HCM). Currently, there is no specific and effective treatment for this disease.
NIAID Data Ecosystem20
