Organocatalyzed Asymmetric α‑Thiocyanation of Oxindoles: Synthesis of Chiral Tertiary 3‑Thiocyanatoxindoles
收藏NIAID Data Ecosystem2026-03-11 收录
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资源简介：
An enantioselective thiocyanation of oxindoles has been developed for the first time using a bifunctional cinchona-derived organo-catalyst and N-thiocyanatophthalimide as the electrophilic thiocyanation source in the presence of 2-naphthol as the additive. Various enantioenriched 3,3′-disubstituted oxindoles with SCN-containing quaternary carbon stereocenters were synthesized under mild conditions in high yields (up to 99%) and good enantioselectivities (up to 6:94 er).
创建时间：
2019-05-31
