Contrast enhanced longitudinal changes observed in an experimental bleomycin-induced lung fibrosis rat model by radial DCE-MRI at 9.4T

The archive contains for the most part the dynamic contrast enhanced UTE MRI data in an experimental bleomycin lung injury model in rats. The data has been reconstructed using a time resolution of 10 seconds. A total of 247 time points are available and cover the 28 minute time period. Gadolinium based contrast agent is injected after 7 minutes. The segmented lung volumes are also part of the archive, for easy lung tissue selection in the data analysis. All images are in Dicom format. The histology data to estimate tissue-air fraction is included as well. Txt files are tables that form the basis for all figures published in the manuscript above. The Bruker raw MRI data, and the scripts to reconstruct the data are not included in this repository due to the file size and due to the fact that the scripts use different software packages (BART toolbox, Bruker library, MiceToolKit nodes). Please contact the author ([e-mail]) if the reconstruction of the images out of the RAW MRI data is to be set up. The necessary scripts will be provided together with some assistance with how to set up the software environment.本归档文件主要包含大鼠博莱霉素诱导肺损伤实验模型中的动态对比增强超短回波时间（Ultra Short Echo Time，UTE）磁共振成像（MRI）数据。该数据以10秒的时间分辨率完成重建，共计包含247个时间点，覆盖总时长28分钟的成像周期。实验于第7分钟时注入钆基对比剂。归档文件中还附带经分割的肺体积数据，便于后续数据分析中快速选取肺组织区域。所有图像均采用Dicom格式存储。此外，归档文件还包含用于估算组织-空气占比的组织学数据。纯文本（Txt）文件为上述论文中所有配图的原始制表依据。 由于文件体积过大，且重建脚本依赖BART工具箱、布鲁克（Bruker）库、MiceToolKit节点等多款软件包，本存储库未包含布鲁克原始MRI数据及图像重建脚本。若需搭建基于原始MRI数据的图像重建流程，请联系作者（邮箱：[e-mail]），我们将提供所需脚本并协助完成软件环境的配置。