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Innate programmable DNA binding by CRISPR-Cas12m effectors enable efficient base editing

NIAID Data Ecosystem2026-05-01 收录

CRISPR碱基编辑

CRISPR-Cas12m效应器

数据链接：

https://www.ncbi.nlm.nih.gov/bioproject/PRJNA1017386 数据链接链接失效反馈

官方服务：

资源简介：

Sequencing data related to CRISPR-Cas12m study.

应用场景：

创建时间：

2023-09-14

CRISPR碱基编辑

心血管疾病基因

Gene-editing technologies, including CRISPR-Cas nucleases and CRISPR base editors, have the potential to permanently modify disease-causing genes in human patients. The demonstration of durable editin

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Highly efficient CRISPR-mediated base editing for the gut Bacteroides spp. with pnCasBS-CBE

肠道菌群基因编辑

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We constructed a pnCasBS-CBE system for base editing in the Bacteroides thetaiotaomicron to expand their genetic toolkit, which can efficiently convert a C:G to a T:A in the genome. As a functional pr

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Table_1_Highly Efficient CRISPR-Mediated Base Editing in Sinorhizobium meliloti.DOCX

CRISPR碱基编辑

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Rhizobia are widespread gram-negative soil bacteria and indispensable symbiotic partners of leguminous plants that facilitate the most highly efficient biological nitrogen fixation in nature. Although

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Homo sapiens Genome sequencing. Homo sapiens

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CRISPR碱基编辑

Recently, base editors, composed of cytidine deaminase, Cas9 nickase (nCas9), and uracil DNA glycosylase inhibitor (UGI), have recently been developed to substitute a C at a target site with T without

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Generating Un1Cas12f1-ABE via RNA-Protein Recruitment Modules

CRISPR碱基编辑

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Optimization of the Un1Cas12f1-ABE constructs, sgRNA scaffold, and deaminase.

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