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SNM1A (DCLRE1A) is crucial for efficient repair of complex DNA breaks in human cells

NIAID Data Ecosystem2026-05-02 收录

数据链接：

https://figshare.com/articles/dataset/SNM1A_DCLRE1A_is_crucial_for_efficient_repair_of_complex_DNA_breaks_in_human_cells/25639521 数据链接链接失效反馈

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Underlying raw data for all all figures.

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创建时间：

2024-06-26

DNA双链断裂修复

NHEJ非同源末端连接

RIF1 acts downstream of 53BP1 to coordinate DNA double strand break repair pathway choice between non-homologous end joining (NHEJ) and homologous recombination (HR). Here we identified ASF1 as an end

NIAID Data Ecosystem160

Cancer Cell Resistance to IFN? Can Occur via Enhanced Double-Strand Break Repair Pathway Activity [CRISPR screen]

癌症免疫治疗耐药性

DNA双链断裂修复

The pleiotropic cytokine interferon-gamma (IFN?) is known to be associated with cytostatic, anti-proliferation, and pro-apoptosis functions in cancer cells. However, cancer cells can become resistant

NIAID Data Ecosystem70

DEtail-seq profiled meiotic DSBs in Saccharomyces cerevisiae

减数分裂机制

DNA双链断裂修复

SPO11-promoted DNA double-strand breaks (DSBs) formation is a crucial step for meiotic recombination, and it is indispensable to detect the broken DNA ends accurately for dissecting the molecular mech

NIAID Data Ecosystem40

Human RECQ1 Interacts with Ku70/80 and Modulates DNA End-Joining of Double-Strand Breaks

DNA双链断裂修复

非同源末端连接

Genomic instability is a known precursor to cancer and aging. The RecQ helicases are a highly conserved family of DNA-unwinding enzymes that play key roles in maintaining genome stability in all livi

NIAID Data Ecosystem70

DMC1 ChIP-seq from B6xCAST F1 PRDM9-Humanized/CAST testes

减数分裂重组

DNA双链断裂修复

We report testis DMC1 enrichment at DSB (Double-Strand Break) hotspots in a B6xCAST F1 mouse, which is heterozygous at Prdm9, with one wild-type CAST allele and one allele found in human populations (

NIAID Data Ecosystem50

SNM1A (DCLRE1A) is crucial for efficient repair of complex DNA breaks in human cells

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