Women of high risk for breast and ovarian cancer

Participants in this cohort are women identified from medical records and family records from the Department of Oncology , Lund. The inclusion criteria is that the woman should belong to families with a high risk of developing breast cancer as well as being known carriers of mutations in BRCA1 or BRCA2, or be related in the first or second generation to an individual with breast cancer or individual without breast cancer who are carriers of mutations in the genes BRCA1 or BRCA2. Study participants must be under 40 years old and still be menstruating. “A family at high-risk for breast cancer” is considered if three women had been diagnosed with breast cancer and at least one of these was below age 50 years at diagnosis, or if two women had been diagnosed with breast cancer and at least one was below age 40 years at diagnosis, or if one woman diagnosed with breast cancer prior to age 30 years. The collection, which is still ongoing, started in 1996 and consisted of 300 cases in 2010. The selected women were contacted with a letter with information about the study and thereafter called and asked if they wanted to participate. A letter containing a comprehensive questionnaire was sent out to the women who had chosen to participate. The questions concerned areas such as fertility , breastfeeding, contraceptives, other medications, smoking and dietary issues. Participants were also called in for sampling and body measuremens (such as weight, length and different breast dimensions). Blood samples were taken on two occasions during the menstrual cycle : day 5-10 and ~ 18-23 days. Purpose: To study risk factors in young women of high risk for breast and ovarian cancer. Data collection is ongoing. In 2010, the study consisted of 300 cases.本队列研究的参与者为从隆德（Lund）肿瘤学部门的医疗记录与家族档案中筛选出的女性。纳入标准如下：女性需属于乳腺癌高风险家族，且为已知的BRCA1或BRCA2基因突变携带者；或其一级/二级亲属为乳腺癌患者，或为携带BRCA1/BRCA2基因突变但未患乳腺癌的个体。研究参与者需未满40周岁且仍处于月经期。 “乳腺癌高风险家族”的判定标准为：家族中有3名女性确诊乳腺癌，且其中至少1名确诊时年龄小于50岁；或有2名女性确诊乳腺癌，且至少1名确诊时年龄小于40岁；或1名女性在30岁前确诊乳腺癌。 本数据收集工作始于1996年，目前仍在进行中，截至2010年已纳入300例受试者。 研究人员先通过信件向筛选出的女性介绍研究相关信息，随后致电确认其是否愿意参与研究。同意参与的女性将收到包含详尽问卷的信函，问卷内容涵盖生育情况、母乳喂养经历、避孕措施、其他用药史、吸烟习惯及饮食相关问题等。参与者还需前往研究中心完成样本采集与身体测量（包括体重、身高及不同乳腺维度指标）。研究人员分别在月经周期的第5-10天和约18-23天两个时段采集血液样本。 研究目的：探究乳腺癌与卵巢癌高风险年轻女性的危险因素。 数据收集工作仍在持续，截至2010年，本研究已纳入300例受试者。