Traditional attempts to model genotoxicity data have been limited to congeneric data sets, primarily because the mechanism of action was ignored, and frequently, the chemicals required metabolism to t
Trivial lethal—atleast one of the reactions in the double deletion pair is lethal in a single reaction deletion Non-trivial lethal, single—reaction involved in the single deletion is lethal Non-trivia
Physiologically-based Pharmacokinetic (PBPK) model of estradiol disposition in humans. Based on Sier et al_2017_estrogen PBPK_simple (MODEL1711210001), but with intrinsic (i.e. liver-mediated) clearan