Phosphine Oxide–Sc(OTf)₃ Catalyzed Highly Regio- and Enantioselective Bromoaminocyclization of (<i>E</i>)‑Cinnamyl Tosylcarbamates. An Approach to a Class of Synthetically Versatile Functionalized Molecules

A highly regio- and enantioselective bromoaminocyclization of (E)-cinnamyl tosylcarbamates catalyzed by a chiral phosphine oxide–Sc­(OTf)3 complex is described. A wide variety of optically active aryl 5-bromo-1,3-oxazinan-2-ones can be obtained with high yield and enantioselectivity.本文报道了由手性膦氧化物-三氟甲磺酸钪（Sc(OTf)3）络合物催化的(E)-肉桂基对甲苯磺酰基氨基甲酸酯的高区域选择性与对映选择性溴氨基环化反应。该反应可高产率、高对映选择性地获得多种光学活性的芳基5-溴-1,3-恶嗪-2-酮类化合物。