DBC1 is a positive regulator of enhancer epigenomic writers KMT2D and p300 [RNA-seq]. DBC1 is a positive regulator of enhancer epigenomic writers KMT2D and p300 [RNA-seq]

We identified DBC1/CCAR2 target genes using RNA-seq analysis in colon cancer cells. Overall design: mRNA profiles of SW480 WT or DBC1 KO cells were generated by deep sequencing, in triplicate, using Illumina HiSeq2500.本研究通过对结肠癌细胞开展RNA测序（RNA-seq）分析，鉴定出DBC1/CCAR2的靶基因。 实验设计概要：采用Illumina HiSeq2500测序平台对SW480野生型（Wild Type, WT）及DBC1敲除（Knock Out, KO）细胞的mRNA表达谱进行深度测序，每组设置三次生物学重复。