RMVar

RMVar 2.0 is an updated database cataloging genetic variants associated with RNA modifications (RMs) in humans and mice, identified using an enhanced pipeline including novel allele-specific RM analysis. It provides comprehensive annotations for these variants, including their effects on post-transcriptional regulation (RBP binding, RNA-RNA interactions, splicing, circRNAs) and integrates disease associations from ClinVar and GWAS to facilitate research into RM-related disease mechanisms.RMVar 2.0是一款更新版数据库，用于收录人类与小鼠中与RNA修饰（RNA Modifications，简称RMs）相关的遗传变异，这些变异通过包含新型等位基因特异性RM分析的增强型分析流程鉴定得到。该数据库为上述变异提供全面注释，包括其对转录后调控（RNA结合蛋白（RNA Binding Protein，简称RBP）结合、RNA-RNA相互作用、RNA剪接、环状RNA（circular RNAs，简称circRNAs））的影响，并整合了来自ClinVar与全基因组关联研究（Genome-Wide Association Study，简称GWAS）的疾病关联数据，以助力RM相关疾病机制的研究。

搜集汇总

背景与挑战

背景概述

RMVar 2.0是一个更新版数据库，收录了人类和小鼠中与RNA修饰相关的遗传变异，并通过增强的分析流程进行识别。该数据库为这些变异提供全面注释，包括对转录后调控的影响，并整合疾病关联数据以支持RNA修饰相关疾病机制研究。